IMMUSYNC^TM is an ayurvedic formulation developed by perfectly synchronizing the immunity boosting powers of ancient herbs. An amalgamation of immuno-modulatory herbs like Guduchi, Ashwagandha, Turmeric, Tulsi, Amla, Haritaki, Bibhitaki, Ginger and Neem, it infuses the body with a spectrum of antioxidants and vitamins which are crucial for a robust immune system. The concentrated active constituents of the above herbs in this medicine amplifies body’s natural resistance to all type of infections.

It busts stress, promotes a good sleep, maintains the gut health and protects all vital organs such as lung, liver, kidney from inflammation, and provides a strong support to maintain healthy immunity inside the body.

INGREDIENTS: Each uncoated tablet contains

Guduchi (Tinospora cordifolia) Ext – 100mg, Aswagandha (Withania somnifera) Ext – 100mg, Turmeric (Curcuma longa) Ext – 100mg, Tulsi (Ocimum sanctum) Ext – 50mg, Amla (Embilica officinalis)Ext – 34mg, Haritaki (Terminalia chebula) Ext – 33mg, Bibhitaki (Terminalia bellerica) Ext – 33mg, Yastimadhu (Glycyrrhiza glabra) Pw – 25mg, Pippali (Piper longum) Pw – 25mg, Black pipper (Pipper nigrum) Pw – 25mg, Sunthi (Zingiber officinale) Pw – 15mg & Neem (Azadiracta indica) Ext – 10mg

IMMUNITY BALANCING PROPERTY OF IMMUSYNC

Immusync is effective in balancing the immune system of body against any foreign attacks or internal stimulus to immune system because of the collective immunity boosting properties of the medicinal herbs used as ingredient in the formulation. Below are the mechanism how these herbs are acting on our immunity system.

GUDUCHI: Guduchi (Tinospora cordifolia), also known as Giloy, is referred as “Amrit” in Sanskrit, meaning “divine nectar”. It is highly valued in Ayurveda for its detoxifying, rejuvenating, immune-boosting, and anti-rheumatic properties. Guduchi enhances the phagocytic activity of macrophages and production of reactive oxygen species (ROS) in human neutrophil cells(1). It also increases proinflammatory cytokines such as IL-1β, IL-6, TNF-α, granulocyte monocyte-colony stimulating factor (GM-CSF).

ASWAGANDHA: Inflammation is a complex immunological process. The initial acute stage of inflammation is mediated through the activation of immune cells, the resultant inflammatory cytokines and intracellular pathways such as Nf-kB. Whithanolides, the active constituent of Ashwagandha, inhibits NF-κB activation and block the expression of LPS- or TNFα-induced NF-κB-regulated inflammatory genes such as iNOS, COX-1, COX-2 and NO. The extract selectively, induces type 1 immunity because it helps enhanced expression of T helper cells (Th1)- cytokine interferon (IFN-gamma) and interleukin (IL-2) while Th2 cytokine IL-4 declines moderately (2).

TURMERIC: Curcumin (20% curcumin in one Immusync tablet) is the active constituent of a Rasayan drug Turmeric and has high safety and low toxicity profile. Infections from viruses as avian influenza, dengue, and coronavirus, can lead to cytokine storms, producing a massive amount of pro-inflammatory cytokines. The collective action of these inflammatory mediators causes the destruction of tissues and cells in lungs and other organs and the clinical syndromes are extensive pulmonary edema, alveolar hemorrhage, ARDS, and multiple organ failures etc. Evidences from preclinical studies have demonstrates that it inhibits viral infection, alleviates the severity of lung injury through offsetting the cytokine storm, inhibits subsequent fibrosis, and increases survival rates (3).

TULSI: Tulsi is rich in Vitamin C and zinc. It has been studied that extract of Tulsi leaves increases the T helper cells and natural killer cells activity and boosts the immune system. Active compounds such as Camphene, cineole, and eugenol present in present in Tulsi extract help to reduce cold and congestion in the chest. Ocimumosides A and B, present in Tulsi leaves reduce stress and effectively boost the immunity, also balance the neurotransmitters serotonin and dopamine in the brain.

It is also observed that it inhibits replication of Corona virus supported with its immune-modulatory feature and ACE II blocking properties. Tulsinol (A, B, C, D, E, F, G) and dihydrodieuginol-B, present in leaves of Tulsi also inhibits SARS Coronavirus Main Protease and Papain-like Protease (4).

SUNTHI : The active components of Ginger rhizome gingerols, shagaols and paradols, etc inhibit prostaglandin and leukotriene biosynthesis, inhibit cyclooxygenase and lipoxygenase activities and inhibit the synthesis of pro-inflammatory cytokines such as IL-1, TNF-α, and IL-8 without any significant effect in IL-6 levels.

BLACK PEPPER: Black Pepper regulates the balance of the cytokines production of Th1, Th2, Th17, and Treg cells, reduces the accumulation of inflammatory cells, inhibit the expressions of pro-inflammatory cytokines (IL-4, IL-6, IL-1β, IL-17A) and TNF-α, increases INF-γ and IL-10 secretions in respiratory track and increases macrophage activation and T and B cell proliferation.

DOSAGE: One tablet twice a day after food or as directed by physician.

SIDE EFFECT:

Pregnant & Breast feeding: Better to avoid during Pregnant and breast feeding stage.

Stomach ulcers: Patients having stomach ulcer should take this under doctor’s supervision.

Auto-immune disease: Patients having multiple sclerosis (MS), lupus, rheumatoid arthritis (RA) should not take.

Surgery: Stop taking it at-least 2 weeks before and after surgery.

Thyroid Disorder: Hyperthyroid patients should avoid taking it.

REFERENCE:

More P, Pai K. In vitro NADH-oxidase, NADPH-oxidase and myeloperoxidase activity of macrophages after Tinospora cordifolia (Guduchi) treatment. Immunopharmacol Immunotoxicol, 2012; 34:368–72.

Davis L, Kuttan G. Effect of Withania Somnifera on cytokine production in normal and cyclophosphamide treated mice. Immunopharmacol Immunotoxicol, 1999; 21(4):695-703.
Liu Z, Ying Y. The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia. Front Cell Dev Biol., 2020; 8:479.

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